Metabolic and redox pathway dysregulation in HIV-associated coronary endothelial dysfunction

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Kshipra S. Keole, Syed Bukhari, Anum Minhas, Charles D. Cohen, Amelia S. Wallace, Damani A. Piggott, Thorsten Martin Leucker, Kevin M Sun, Luigi Adamo, Allison G. Hays
DOI: 10.1152/ajpheart.00032.2026
Cited by: 0
References: 32

Abstract

Background: People with HIV (PWH), even with sustained viral suppression on antiretroviral therapy (ART), remain at increased risk for cardiovascular disease. Coronary endothelial dysfunction, a sensitive marker of early vascular injury and a potential target for intervention is common in this population, but its biological basis remains unknown. Methods: coronary MRI and high-throughput serum proteomics to investigate mechanisms of coronary endothelial dysfunction in treated HIV. Forty-five virally suppressed PWH and twenty-nine age- and sex-matched healthy controls underwent coronary MRI during isometric handgrip exercise to quantify coronary endothelial function, defined as the percentage change in coronary cross-sectional area (%CSA) from rest to stress. An increase in coronary CSA

Fields of Study & Subjects

HIV-related health complications and treatments Cardiovascular Health and Disease Prevention Cardiovascular Disease and Adiposity

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
331
Issue
2
Pages
H490–H497
Publication date
16 June 2026
Language
EN