Parental obesity exacerbates cognitive dysfunction and cardiac vulnerability in offspring of an Alzheimer disease model

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Jussara Marcia do Carmo, John E. Hall, Emily Ladnier, Xuemei Dai, Zhen Wang, Alan J. Mouton, Ana C. M. Omoto, Luciana Jorge, Alexandre A. da Silva
DOI: 10.1152/ajpheart.00047.2026
Cited by: 1
References: 47

Abstract

Parental obesity is associated with worsened cognitive performance and male-specific impairments in cardiac metabolism and function in AD-susceptible offspring, highlighting developmental programming as a modifier of heart-brain vulnerability.

Fields of Study & Subjects

Dementia and Cognitive Impairment Research Cardiovascular Function and Risk Factors Alzheimer's disease research and treatments

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
6
Pages
H1827–H1840
Publication date
24 April 2026
Language
EN