The nuclear receptor ROR-alpha is a putative novel myogenic regulator of the cardiomyocyte transcriptome, including the alpha-1A adrenergic receptor

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Raghu Sundaresan Nagalingam, Ju Youn Beak, Richard D. Lutze, Wei Huang, Dhiren Akkina, Christina Kang, Anyue Zhao, Britney Alcira, A Aghajanian, Kevin Gerrish, Hong Soon Kang, Anton M. Jetten
+1 more Brian C. Jensen
DOI: 10.1152/ajpheart.00054.2026
Cited by: 1
References: 63

Abstract

The transcriptomic landscape of retinoic acid-related orphan nuclear receptor alpha (RORα) in the heart is defined for the first time. It includes key sarcomeric genes and other myogenic transcription factors. RORα is identified as the first bona fide transcriptional regulator of cardiac alpha-1A adrenergic receptor (α1A-AR) abundance, acting through direct binding to the Adra1a promoter to enhance its expression in cardiomyocytes, particularly under hypoxic stress. Cardiac α1A-ARs exhibit synchronous circadian oscillation with RORα, potentially revealing a previously unrecognized rhythmic regulatory axis.

Fields of Study & Subjects

Circadian rhythm and melatonin Renin-Angiotensin System Studies Adipose Tissue and Metabolism

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
331
Issue
2
Pages
H509–H522
Publication date
25 June 2026
Language
EN