Reductions in myocardial interstitial fibrosis are dissociated from LV chamber stiffness in swine with repetitive pressure overload
Abstract
Swine with increased left ventricular (LV) chamber stiffness and fibrosis from 2 wk of repetitive pressure overload demonstrated discordant effects following two disparate antifibrotic interventions. A single infusion of intracoronary allogeneic cardiosphere-derived cells and 4 wk of oral finerenone each effectively reduced myocardial interstitial fibrosis. Despite reversal of fibrosis, LV chamber stiffness did not improve with either intervention, suggesting that myocyte-dependent mechanisms may play an important role in diastolic dysfunction from intermittent hemodynamic overload.
Fields of Study & Subjects
Cardiac Fibrosis and Remodeling
Cardiovascular Function and Risk Factors
Congenital heart defects research
Publication details
- Journal / source
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 5
- Pages
- H1394–H1404
- Publication date
- 12 March 2026
- Language
- EN