Long-term genetic Orai1 inhibition modulates excitation-contraction coupling in female adult mouse ventricular cardiomyocytes

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

Read full text
Authors: Fiona Bartoli, Pauline Le Gourriérec, Baptiste Rode, Fabrice Antigny, Romain Perrier, David Beech, A M Morales Gómez, Jean‐Pierre Bénitah, Jessica Sabourin
DOI: 10.1152/ajpheart.00101.2026
Cited by: 1
References: 33

Abstract

This short report reveals a novel mechanistic contribution of the Ca 2+ channel Orai1 to sexual dimorphism in cardiac physiology. We demonstrated that the chronic functional suppression of Orai1 abrogates sex differences in cardiomyocyte excitation-contraction coupling.

Fields of Study & Subjects

Ion Channels and Receptors Wnt/β-catenin signaling in development and cancer Cardiac electrophysiology and arrhythmias

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
5
Pages
H1702–H1710
Publication date
2 April 2026
Language
EN