Myocardial expression of ADGRL4 and AQP7 is related to regression of left ventricular hypertrophy after aortic valve replacement in a sex-dependent manner

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Kristján Bjarki Halldórsson, Korina Karagianni, Adelino F. Leite-Moreira, Dimitra Dafou, Inês Falcão‐Pires, Georgios Kararigas
DOI: 10.1152/ajpheart.00188.2026
Cited by: 1
References: 63

Abstract

Regression of left ventricular hypertrophy is associated with better long-term outcome. This study demonstrates a significant relationship between ADGRL4 and AQP7 gene expression in perioperatively collected myocardial tissues and the regression of left ventricular mass postoperatively in male patients with aortic stenosis only. This could contribute to the development of a sex-based tool to predict the extent of postoperative hypertrophy regression.

Fields of Study & Subjects

Cardiac Valve Diseases and Treatments Congenital heart defects research Cardiomyopathy and Myosin Studies

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
331
Issue
1
Pages
H1–H10
Publication date
21 May 2026
Language
EN