Regional heterogeneity and sex differences along the mouse aorta

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Timothy M. Sveeggen, Anna Kosmach, Ray Mitchell, Benjamin C. Brockmann, Trevor M. Meisinger, Amber N. Stratman, Julia J. Mack, Jason R. Cook, Pooneh Bagher
DOI: 10.1152/ajpheart.00209.2026
Cited by: 1
References: 86

Abstract

We systematically assessed vasoreactivity of multiple aortic regions in male and female wild-type mice via wire myography. We observed regional and sex differences in vasoreactivity along the aorta, suggesting that the mouse aorta is heterogeneous and not a uniform conduit vessel for blood distribution. Notably, the infrarenal aorta was unique in its vasomotor responses. These data serve as a reference for assay design of aortic function in disease states and highlight region-specific sex differences.

Fields of Study & Subjects

Nitric Oxide and Endothelin Effects Cardiovascular Health and Disease Prevention Angiogenesis and VEGF in Cancer

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
331
Issue
2
Pages
H384–H406
Publication date
10 June 2026
Language
EN