Sex differences in the peripheral determinants of oxygen transport and utilization in patients with heart failure with preserved ejection fraction

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Christopher M. Hearon Jr., Rachel J. Skow, Denis J. Wakeham, Claire Kissell, Tiffany L. Brazile, Michael D. Nelson, Miles F. Bartlett, Jimin Ren, Mitchel R. Samels, James P. MacNamara, Ziba Taherzadeh, Kevin Lutz
+4 more Benjamin D. Levine, Paul J. Fadel, Mark J. Haykowsky, Satyam Sarma
DOI: 10.1152/ajpheart.00254.2026
Cited by: 1
References: 72

Abstract

Females with heart failure with preserved ejection fraction have lower muscle oxygen diffusive conductance during peak exercise compared with males. Interventions to improve muscle quality and diffusive capacity are of particular importance for improving peripheral limitations to exercise in females with HFpEF.

Fields of Study & Subjects

Cardiovascular and exercise physiology Cardiovascular Function and Risk Factors Nutrition and Health in Aging

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
331
Issue
1
Pages
H11–H22
Publication date
21 May 2026
Language
EN