Modeling sex-dependent cardiovascular responses to lower body negative pressure
Abstract
We present the first lumped-parameter cardiovascular model calibrated to sex-specific hemodynamic responses during graded lower body negative pressure, integrating internal jugular and portal venous flow as calibration targets. Baseline identification reveals coherent structural sex differences: females exhibit higher splanchnic and renal vascular resistance, and males exhibit higher lower-limb resistance and arterial compliance. Across all LBNP levels, splanchnic vasoconstriction emerges as the dominant compensatory pathway in both sexes, whereas lower-limb resistance diverges markedly between sexes.
Fields of Study & Subjects
Hemodynamic Monitoring and Therapy
Cardiac Arrest and Resuscitation
Heart Rate Variability and Autonomic Control
Publication details
- Journal / source
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Volume
- 331
- Issue
- 1
- Pages
- H240–H259
- Publication date
- 29 May 2026
- Language
- EN