ERBB4 activation prevents microvascular dysfunction in a large animal model of hypertensive heart disease

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Michiel R. L. Tubeeckx, Tijs Bringmans, Bo Goovaerts, Siel Van den Bogaert, M Grootaert, Elizabeth AV Jones, Petra Korpisalo, Greta Juusola, Galina Wirth, Samuel L. Murphy, Hein Heidbuchel, Gilles W. De Keulenaer
+1 more Vincent F. M. Segers
DOI: 10.1152/ajpheart.00303.2025
Cited by: 1
References: 44

Abstract

CMD is implicated in numerous cardiac diseases, for which only a few therapeutic options are available. Stimulation of the ERBB4/NRG1 pathway has shown beneficial effects in preclinical models of heart failure. JK07 is a selective ERBB4 agonist of interest. JK07 was able to prevent the increase in microvascular resistance in a DOCA-induced hypertensive pig model, as measured by the bolus thermodilution method.

Fields of Study & Subjects

HER2/EGFR in Cancer Research Cardiac Fibrosis and Remodeling Atherosclerosis and Cardiovascular Diseases

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
6
Pages
H2025–H2035
Publication date
19 May 2026
Language
EN