Loading conditions rather than contractility primarily determine biventricular ejection fraction in endotoxic shock

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Manuel Ignacio Monge García, Brennan Schneider, George Ma, Feras Hatib, Zhongping Jian, Jos J. Settels, Ignacio Fernández, Thomas Scheeren, Michael R. Pinsky
DOI: 10.1152/ajpheart.00355.2026
Cited by: 1
References: 52

Abstract

This study provides a simultaneous quantification of six hemodynamic determinants of both left and right ventricular ejection fraction during endotoxic shock and resuscitation using biventricular pressure-volume analysis. Loading conditions dominated over contractility, and the determinant hierarchy differed between ventricles.

Fields of Study & Subjects

Sepsis Diagnosis and Treatment Hemodynamic Monitoring and Therapy Trauma Hemostasis Coagulopathy Resuscitation

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
331
Issue
3
Pages
H817–H831
Publication date
28 July 2026
Language
EN