Neuregulin-1β augments adaptive concentric remodeling and systolic function without exacerbating hypertrophy during pressure overload

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Lifen Xu, Parisa Aghagolzadeh, C Morandi, Jasmin Wagner, Lilia Maryse Lépine, Vincent F. M. Segers, Gilles W. De Keulenaer, Marijke Brink
DOI: 10.1152/ajpheart.00371.2025
Cited by: 0
References: 91

Abstract

Our study demonstrates that neuregulin-1β (NRG1) enhances systolic function during pressure overload while promoting adaptive remodeling without exacerbating hypertrophy. NRG1 regulates fetal gene programs in both sexes and reduces fibrosis in male mice. The identification of myosin binding protein C ( Mybpc2) and Popeye domain-containing protein 2 ( Popdc2) as novel NRG1-responsive genes reveals previously unrecognized mechanisms underlying its cardioprotective effects. These findings support further investigation of NRG1-based therapeutic strategies and highlight potential sex-specific responses.

Fields of Study & Subjects

Cardiac Fibrosis and Remodeling Cardiomyopathy and Myosin Studies Signaling Pathways in Disease

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Volume
330
Issue
3
Pages
H818–H837
Publication date
3 February 2026
Language
EN