Hemodynamics and transplacental oxygen exchange during intact cord resuscitation in control and congenital diaphragmatic hernia lambs

American Journal of Physiology-Heart and Circulatory Physiology 2026

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Authors: Kévin Le Duc, Florian Manœuvrier, Céline Rougraff, Baptiste Teillet, Patrice Maboudou, Anne Wojtanowski, Capucine Besengez, Geoffroy Chevalier, Louise Ghesquiere, Charles Garabédian, Sébastien Mur, Mohamed Riadh Boukhris
+2 more Laurent Storme, Dyuti Sharma
DOI: 10.1152/ajpheart.00388.2025
Cited by: 0
References: 34

Abstract

Maternal anesthesia with halogenated gas sustains placental circulation for 1 h postbirth. Intact cord resuscitation supports oxygenation (placental oxygen transfer ∼2.7 mL/kg/min) for 1 h in the congenital diaphragmatic hernia (CDH) lamb model. Maintaining feto-placental circulation during delivery room resuscitation in the context of CDH ensures continuous oxygenation and carbon dioxide clearance for up to 1 h.

Fields of Study & Subjects

Congenital Diaphragmatic Hernia Studies Neonatal Respiratory Health Research Respiratory Support and Mechanisms

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Volume
330
Issue
4
Pages
H946–H954
Publication date
29 January 2026
Language
EN