Integrated left ventricular mass and left atrial function for prediction of cardiovascular outcomes: the Multi-Ethnic Study of Atherosclerosis

American Journal of Physiology-Heart and Circulatory Physiology 2026

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Authors: Elio Salameh, Malak M. Hoballah, Elnaz Ebrahimihoor, Aysa Ostovaneh, Colin O. Wu, Robyn Mcclelland, Steven Shea, David A. Bluemke, Bharath Ambale-Venkatesh, João A.C. Lima
DOI: 10.1152/ajpheart.00397.2026
Cited by: 1
References: 40

Abstract

Left atrial failure underlies two of the most consequential conditions in cardiovascular medicine: atrial fibrillation, with predisposition to stroke and dementia, and heart failure with preserved ejection fraction, a leading cause of hospitalization and mortality. By examining the relationship between left ventricular hypertrophy and left atrial deformation at the population level, we demonstrate that the LV mass-to-LA strain ratio identifies a threshold beyond which adverse atrial remodeling independently predicts incident cardiovascular events-even within normal ranges.

Fields of Study & Subjects

Cardiovascular Function and Risk Factors Cardiac Imaging and Diagnostics Cardiovascular Disease and Adiposity

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
331
Issue
3
Pages
H806–H816
Publication date
30 July 2026
Language
EN