Modulation of macrophage polarization with acute administration of Vericiguat after myocardial infarction

American Journal of Physiology-Heart and Circulatory Physiology 2026

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Authors: Thomas Dempster, Alexa Corker, Kim N. Vu, Miguel Troncoso, Norma Bradley, Amber Hazzard, Kailee Milligan, Bryce Macaulay, S. Dasgupta, Mei Li, Kristine Y. DeLeon-Pennell
DOI: 10.1152/ajpheart.00626.2025
Cited by: 2
References: 45

Abstract

Acute administration of Vericiguat after myocardial infarction alters macrophage phenotype but not cell numbers. Macrophages from Vericiguat-treated mice led to more robust endothelial cell tubule formation. Acute administration of Vericiguat stimulates macrophages toward a proangiogenic phenotype that was more exaggerated in females.

Fields of Study & Subjects

Cardiac Fibrosis and Remodeling Heart Failure Treatment and Management Cardiac electrophysiology and arrhythmias

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
H890–H903
Publication date
16 February 2026
Language
EN