Sex and stimulus-specific differences in endothelial cell senescence under hormone-free conditions

American Journal of Physiology-Heart and Circulatory Physiology 2026

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Authors: Anna Quarder, Khaoula Talbi, Hannah Bartmann, Esther Beuke, Constantin von Kaisenberg, Manuel M. Vincente, Sara Todorovic, A Melk
DOI: 10.1152/ajpheart.00646.2025
Cited by: 1
References: 46

Abstract

This study reveals intrinsic, hormone-independent sex differences in endothelial cell senescence. Female HUVECs exhibit delayed replicative but enhanced stress-induced senescence compared with male cells. These opposing responses highlight that sex-specific mechanisms in vascular aging depend on the type of senescence stimulus. By using hormone-free conditions, the study underscores the importance of intrinsic cellular factors in endothelial biology and suggests that sex should be considered when investigating and targeting vascular aging and disease.

Fields of Study & Subjects

Telomeres Telomerase and Senescence Menopause: Health Impacts and Treatments Nitric Oxide and Endothelin Effects

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
H515–H523
Publication date
9 January 2026
Language
EN