Comprehensive transcriptomics and proteomics analysis of neointima formation in human saphenous vein: implications for bypass graft disease

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: David Kim, Brandee Goo, Hong Shi, Shuilin Dong, Daniel S. Weintraub, Philip Coffey, Praneet Veerapaneni, Ronnie Chouhaita, Medha Guduru, Nicole Cyriac, Ghaith Aboud, Vy Ong
+20 more Stephen Cave, Jacob Greenway, Rohan Mundkur, Samah Ahmadieh, Ragheb Harb, Mourad Ogbi, D.B. Fulton, Yuqing Huo, Wei Zhang, Xiaochun Long, Avirup Guha, Ha Won Kim, Yang Shi, Robert D. Rice, Jiang Zhou, Austin W.T. Chiang, Dominic R. Gallo, Vijay Patel, Richard Lee, Neal L. Weintraub
DOI: 10.1152/ajpheart.00653.2025
Cited by: 2
References: 72

Abstract

Using multiomics and spatial transcriptomics, we uncover dynamic molecular and cellular changes driving neointima proliferation in human saphenous veins, the most common conduit for bypass surgery. Our study highlights sex- and body mass index-associated differences, novel fibroblast and smooth muscle cell states, and a role for microRNA-647 in preserving vascular contractile phenotype. These findings provide new insight into the mechanisms of vein graft failure and may guide future strategies to improve coronary bypass outcomes.

Fields of Study & Subjects

Coronary Interventions and Diagnostics Cardiac and Coronary Surgery Techniques Blood properties and coagulation

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
H620–H641
Publication date
22 January 2026
Language
EN