Periostin contributes to differential sex-linked gene expression during infarct healing

American Journal of Physiology-Heart and Circulatory Physiology 2026

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Authors: Besher Abual’anaz, Lucien G.J. Cayer, Sara S. Haji Rasul, Sunil G. Rattan, Jonathon C. Lambos, Taylor I. M. Evans, Inna Rabinovich-Nikitin, LA Kirshenbaum, Petra C. Kienesberger, Jeffrey T. Wigle, Michael P. Czubryt, Ian Dixon
DOI: 10.1152/ajpheart.00675.2025
Cited by: 2
References: 57

Abstract

We determined that cardiac wound healing following MI is periostin (Postn) dependent in male mice but Postn independent in female mice. To date, previous Postn knockout (KO) studies have exclusively used male animals. The current experimental design includes both sexes and reveals that the underlying mechanism of action to be sex dependent. Specifically, changes in the expression of collagen synthesis and cross-linking genes in the infarct scar are dependent on Postn expression in males only.

Fields of Study & Subjects

Cardiac Fibrosis and Remodeling Cardiovascular Function and Risk Factors Congenital heart defects research

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
H927–H943
Publication date
16 February 2026
Language
EN