Sex-specific responses in the early stages of diet-induced cardiovascular-kidney-metabolic syndrome

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Abhipree Sharma, Minh Deo, K C Khe Tran, N. Jennifer Tang, Tayla Bishop, Alexander N. Parker, Nimna Perera, Anida Mesinovic, Ryan Gillis, Abdullah‐Al Mamun, Thanh-Nhan Nguyen, Dovile Anderson
+3 more David M. Shackleford, Miles J. De Blasio, Rebecca Helen Ritchie
DOI: 10.1152/ajpheart.00724.2025
Cited by: 1
References: 120

Abstract

High-fat diet (HFD) feeding exerts modest cardiometabolic dysfunction in mice, with changes more apparent in female mice. Dapagliflozin treatment exerts sex-specific effects on glucose tolerance and measures of renal injury, even at lower doses, in males. Female mice are more prone to renal dysfunction, indicating the importance of interrogating sex differences in animal models and treatments for cardiovascular-kidney-metabolic (CKM) syndrome.

Fields of Study & Subjects

Chronic Kidney Disease and Diabetes Diabetes Treatment and Management Cardiovascular Function and Risk Factors

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
331
Issue
2
Pages
H600–H618
Publication date
7 July 2026
Language
EN