Contributions of cardiac output and total peripheral resistance to interindividual variability in peak exercise blood pressure in young adults

American Journal of Physiology-Heart and Circulatory Physiology 2026

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Authors: Gabriel S. Romano, Tanvir S Matharu, Devin G. McCarthy, Johan S. Thiessen, Rileigh K Stapleton, Julian C. Bommarito, Sydney E Hilton, Rena K. Chang, Jamie F. Burr, Philip J. Millar
DOI: 10.1152/ajpheart.00727.2025
Cited by: 5
References: 44

Abstract

Whether interindividual differences in exercise blood pressure (BP) are mediated by changes in cardiac output or total peripheral resistance remain unclear. We demonstrate in healthy normotensive adults that higher peak exercise systolic BP during cycling is related to a larger cardiac output, whereas the rise in systolic BP per metabolic equivalent is related to a diminished fall in total peripheral resistance. Sex also appears to modulate this relation in those with an exaggerated exercise BP.

Fields of Study & Subjects

Cardiovascular and exercise physiology Heart Rate Variability and Autonomic Control Cardiovascular Effects of Exercise

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
H909–H918
Publication date
19 February 2026
Language
EN