Endothelial sensitivity to exercise-induced shear rate in older adults: effect of biological sex and acute folic acid consumption

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Katia Oubouchou, Amélie Debray, Nicholas Ravanelli, Yousra Ouazaa, Jinan Saboune, Charlotte W. Usselman, Steven A. Romero, Daniel Gagnon
DOI: 10.1152/ajpheart.00733.2025
Cited by: 2
References: 19

Abstract

We hypothesized that endothelial sensitivity to exercise-induced shear rate is reduced in healthy postmenopausal females. In contrast to this hypothesis, endothelial sensitivity to increases in shear rate caused by handgrip exercise did not differ between healthy postmenopausal females and males of similar age. These results suggest that a reduced endothelial sensitivity to exercise-induced shear rate may not contribute to the inconsistent effect of aerobic exercise interventions on brachial artery flow-mediated dilation in healthy postmenopausal females.

Fields of Study & Subjects

Cardiovascular Health and Disease Prevention Blood properties and coagulation Parathyroid Disorders and Treatments

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
H445–H452
Publication date
7 January 2026
Language
EN