Multicomponent intervention improves gut microbiome and cardiac autonomic function in childhood obesity

American Journal of Physiology-Heart and Circulatory Physiology 2026

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Authors: Paulo César Trindade da Costa, Marciane Magnani, Vinicius José Baccin Martins, Rúbia Cartaxo Squizato de Moraes, Cristiane Cosmo Silva-Luis, José Milton de Araújo Rodrigues, Lucélia Cabral, Melline Fontes Noronha, Oriane Vitalis, K. Chikh, M. Godet, Hubert Vidal
+1 more José Luiz de Brito Alves
DOI: 10.1152/ajpheart.00769.2025
Cited by: 1
References: 61

Abstract

), circulating metabolites, and cardiovascular autonomic indices, supporting the existence of microbiota-metabolite-heart interactions. In summary, a 4-month multicomponent lifestyle intervention improved cardiovascular autonomic function, inflammatory status, and cardiometabolic profiles in children with obesity. These findings highlight the cardiovascular benefits of early lifestyle modification and support integrative approaches targeting autonomic and metabolic pathways in pediatric obesity.

Fields of Study & Subjects

Gut microbiota and health Heart Rate Variability and Autonomic Control Cardiovascular Health and Risk Factors

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
H799–H812
Publication date
4 February 2026
Language
EN