Relative aortic valve stiffness: a new parameter quantifying aortic stenosis

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Eric Buffle, Athanasios Papadis, Isaac Blaser, Nikolas Nozica, Mohammad Kassar, Roger Ludwig, David Berger, Matthias Hänggi, Marco Mauri, Dominik Obrist, Christian Seiler, Stefano Fausto de Marchi
DOI: 10.1152/ajpheart.00804.2025
Cited by: 1
References: 21

Abstract

Aortic stenosis (AS) quantification relies on transvalvular gradients or aortic valve opening area (AVA). We present a new quantification method for AS based on new modeling of the aortic valve opening behavior. We fitted a sigmoid relation between flow rate and AVA and retrieved the "relative aortic valve stiffness" (rAVS). We could demonstrate its superior association with clinical endpoints compared with previous models in AS and provide a simple tool for its calculation using echocardiography.

Fields of Study & Subjects

Cardiac Valve Diseases and Treatments Cardiovascular Function and Risk Factors Aortic Disease and Treatment Approaches

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
H1331–H1339
Publication date
27 February 2026
Language
EN