Combined high-fat, high-sucrose diet and streptozotocin treatment induces cardiometabolic heart failure with preserved ejection fraction in mice

American Journal of Physiology-Heart and Circulatory Physiology 2026

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Authors: Andre Heinen, André Spychala, Lucas Ballmann, Stefanie Gödecke, Zewa Faradj, Florian Bresch, Martina Krüger, Katharina Bottermann, Heba Zabri, J.W. Fischer, Patrick Petzsch, A. Gödecke
DOI: 10.1152/ajpheart.00843.2025
Cited by: 4
References: 55

Abstract

Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome whose pathophysiological mechanisms are incompletely understood, potentially due to a lack of preclinical models reflecting the broad range of pathophysiological aspects. We describe a diabetic DIO-STZ mouse model showing a pronounced HFpEF with underlying mechanisms that remarkably differ from other HFpEF models, making this model a relevant extension of the range of HFpEF models, especially for investigating molecular mechanisms or therapeutical interventions in diabetes.

Fields of Study & Subjects

Cardiovascular Function and Risk Factors Cardiovascular Disease and Adiposity Cardiac Fibrosis and Remodeling

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
5
Pages
H1375–H1390
Publication date
18 March 2026
Language
EN