Decoding atrial mechanics: human atrial slices as a model for atrial disease

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Elisa C. H. van Doorn, Lu Zhang, Kevin M. Veen, Jorik H. Amesz, Jolanda Kluin, Natasja M. S. de Groot, Yannick J.H.J. Taverne
DOI: 10.1152/ajpheart.00850.2025
Cited by: 0
References: 61

Abstract

Human atrial living myocardial slices (LMS) bridge the gap between clinical disease and tissue-level mechanistic insight. Using the largest dataset of human atrial slices to date, this study maps the biomechanical landscape of the atrium and reveals preserved disease-specific signatures in vitro. These findings position LMS as a promising platform for studying atrial pathophysiology and therapeutic development.

Fields of Study & Subjects

Cardiac electrophysiology and arrhythmias Cardiovascular Function and Risk Factors Cardiac Fibrosis and Remodeling

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Volume
330
Issue
3
Pages
H757–H774
Publication date
29 January 2026
Language
EN