Gestational diabetes promotes future maternal cardiovascular disease through endothelin activation and suppressed NO/cGMP/PRKG and AMPK/SIRT1 signaling pathways

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Olufunto Olayinka Badmus, Sally Wahba, Gertrude Arthur, Landon D. Parrow, Brodrick Montgomery, Isabela Garibaldi Cucolicchio, Karis McGowan, Erin B. Taylor
DOI: 10.1152/ajpheart.00871.2025
Cited by: 1
References: 83

Abstract

Mechanisms underlying the future development of CVD in mothers with GDM were investigated using a mouse model of GDM that mimics the condition observed in human GDM. Examining the aorta in the later life of the GDM model reveals increased arterial stiffness and endothelin activation associated with vascular remodeling. In addition, kinome analysis reveals suppressed cardiac NO/cGMP/PRKG and impaired AMPK-SIRT1 signaling pathways, which corroborate the impaired ventricular relaxation observed in later life in GDM mothers.

Fields of Study & Subjects

Gestational Diabetes Research and Management Pregnancy and preeclampsia studies Nitric Oxide and Endothelin Effects

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
331
Issue
3
Pages
H753–H773
Publication date
1 August 2026
Language
EN