Vascular endothelial function is preserved in women with a history of preeclampsia currently receiving antidepressant pharmacotherapy

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Ruda Lee, Jody L. Greaney, Mark K. Santillan, Gary L. Pierce, Anna E. Stanhewicz
DOI: 10.1152/ajpheart.00890.2025
Cited by: 1
References: 31

Abstract

To our knowledge, this is the first study to demonstrate that chronic antidepressant use is associated with preserved endothelial function in women with a history of preeclampsia (hxPE). Compared with healthy controls, untreated women with hxPE had reduced macrovascular (brachial artery) and microvascular (cutaneous) endothelial function, whereas those treated with antidepressants exhibited preserved endothelial function. These findings suggest that antidepressants may modulate persistent endothelial dysfunction in these women following preeclampsia.

Fields of Study & Subjects

Pregnancy and preeclampsia studies Menopause: Health Impacts and Treatments Maternal Mental Health During Pregnancy and Postpartum

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
H524–H530
Publication date
14 January 2026
Language
EN