Brief repetitive pressure overload in mice induces eccentric remodeling and impaired contractile reserve
Abstract
This study introduces a novel murine model of RPO using serial phenylephrine infusions to mimic chronic episodic hemodynamic stress. Unlike porcine models of RPO that demonstrate increased LV chamber stiffness and protection against strain-induced myocyte injury, mice exhibit reduced LV chamber stiffness and persistent myocyte apoptosis that is accompanied by loss systolic dysfunction with a preserved ejection fraction at rest. These findings indicate important species differences in the response to transient pressure overload.
Fields of Study & Subjects
Cardiac Fibrosis and Remodeling
Cardiovascular Function and Risk Factors
Cardiac electrophysiology and arrhythmias
Publication details
- Journal / source
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Volume
- 331
- Issue
- 1
- Pages
- H58–H66
- Publication date
- 21 May 2026
- Language
- EN