Cardiac mitochondrial proteome of lean, healthy Ossabaw minipigs with predisposition to metabolic syndrome versus that of Göttingen minipigs

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Chantal Eickelmann, Nilgün Gedik, Helmut Raphael Lieder, Laxmikanth Kollipara, Albert Sickmann, Michael S. Sturek, Gerd Heusch, Petra Kleinbongard
DOI: 10.1152/ajpheart.00905.2025
Cited by: 1
References: 83

Abstract

Our comprehensive cardiac mitochondrial proteome of Ossabaw and Göttingen minipigs is a valuable resource for cardiac biomedical research. Moreover, our proteome analysis provides a broader basis for understanding how genetic alterations result in changes of the mitochondrial proteome and support a mechanistic link between subtle, strain-specific mitochondrial proteomic signatures and altered mitochondrial energy turnover. These changes may be relevant for the development and progression of metabolic syndrome and/or primordial nonresponsiveness to cardioprotection in Ossabaw minipigs.

Fields of Study & Subjects

Mitochondrial Function and Pathology Adipose Tissue and Metabolism Xenotransplantation and immune response

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
H854–H868
Publication date
5 February 2026
Language
EN