Linking maternal and neonatal circulation in preeclampsia

American Journal of Physiology-Heart and Circulatory Physiology 2026 Open access

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Authors: Federica Piani, Lorenzo Annesi, D. Degli Esposti, Sofia Vincenzi, Sara De Crescenzo, Anna Nunzia Della Gatta, G. Simonazzi, Luigi Corvaglia, Silvia Martini
DOI: 10.1152/ajpheart.00945.2025
Cited by: 4
References: 46

Abstract

This study provides the first evidence that maternal cardiovascular maladaptation in preeclampsia is directly mirrored in neonatal hemodynamics. Newborns displayed a compensatory rise in cardiac output in response to maternal systolic dysfunction, whereas changes in neonatal vascular tone remained minimal. Although maternal and neonatal circulations are traditionally examined independently, these findings underscore a tightly linked maternal-fetal hemodynamic dyad, offering new insight into the physiological continuity that spans the perinatal transition.

Fields of Study & Subjects

Pregnancy and preeclampsia studies Neonatal and fetal brain pathology Gestational Diabetes Research and Management

Publication details

Journal / source
American Journal of Physiology-Heart and Circulatory Physiology
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
H708–H716
Publication date
12 January 2026
Language
EN