Lipidomic remodeling is associated with hemodynamic severity in calcific aortic valve stenosis
Abstract
Our study delivers the largest lipidomic analysis of human aortic valves, revealing early metabolic shifts, especially in diacylglycerols and alkyl-lysophosphatidylcholines that closely track hemodynamic severity. By integrating valve tissue and plasma profiles, we identify triglycerides TG 52:4 and TG 54:4 as promising noninvasive candidate biomarkers. These findings clarify lipid-driven mechanisms of calcific aortic stenosis and highlight new opportunities for earlier detection and risk stratification.
Fields of Study & Subjects
Cardiac Valve Diseases and Treatments
Aortic Disease and Treatment Approaches
Lipoproteins and Cardiovascular Health
Publication details
- Journal / source
- American Journal of Physiology-Heart and Circulatory Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 6
- Pages
- H2036–H2055
- Publication date
- 13 May 2026
- Language
- EN