Cardiovascular scaling between humans and mice during postnatal development
Abstract
This study provides the first cardiovascular-specific, quantitative mapping of postnatal developmental time between humans and mice. By integrating anatomical, functional, and biomechanical data, we show that no single age scale factor can align cardiovascular maturation across species, although 0.69 mouse weeks per human year is the overall optimum. Variable-specific scaling better captures cross-species differences, particularly between structural growth and hemodynamic maturation. These results offer a practical framework to improve age selection and translational relevance in pediatric cardiovascular mouse studies.
Fields of Study & Subjects
Animal testing and alternatives
Pharmaceutical studies and practices
Cardiovascular Function and Risk Factors
Publication details
- Journal / source
- American Journal of Physiology-Heart and Circulatory Physiology
- Volume
- 330
- Issue
- 4
- Pages
- H1129–H1140
- Publication date
- 4 March 2026
- Language
- EN