Single-beat method echocardiographic comparison of ventricular-arterial coupling in adults with and without Down syndrome
Abstract
This study reveals, for the first time, that adults with Down syndrome exhibit significantly lower ventricular-arterial coupling ratios, reflecting distinct cardiac timing and functional adaptations. These findings could indicate a compensatory mechanism to maintain cardiac output despite reduced diastolic pressure and smaller cardiac chambers, providing novel insight into the integrated cardiovascular physiology of adults with Down syndrome and its potential implications for exercise tolerance and long-term cardiovascular health.
Fields of Study & Subjects
Cardiovascular Function and Risk Factors
Down syndrome and intellectual disability research
Cardiovascular and exercise physiology
Publication details
- Journal / source
- American Journal of Physiology-Heart and Circulatory Physiology
- Volume
- 330
- Issue
- 3
- Pages
- H664–H670
- Publication date
- 20 January 2026
- Language
- EN