A biomimetic miniaturized in vitro model to target early markers of neonatal pulmonary vascular injury

American Journal of Physiology-Lung Cellular and Molecular Physiology 2026 Open access

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Authors: Motaharehsadat Heydarian, Ali Doryab, Juan Henao, Benjamin Schubert, Otmar Schmid, Anne Hilgendorff
DOI: 10.1152/ajplung.00002.2026
Cited by: 1
References: 52

Abstract

We present a biomimetic, miniaturized in vitro model that replicates key features of neonatal pulmonary vascular injury. By integrating physiologically relevant cues, this platform enables early detection of injury-associated molecular markers and mechanistic interrogation of disease onset. This scalable model offers a powerful tool for studying neonatal lung vascular pathology and for accelerating the discovery of early diagnostic and therapeutic strategies.

Fields of Study & Subjects

Neonatal Respiratory Health Research Connective tissue disorders research Pulmonary Hypertension Research and Treatments

Publication details

Journal / source
American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher
American Physiological Society
Volume
331
Issue
1
Pages
L92–L104
Publication date
9 June 2026
Language
EN