Early detection of small airway dysfunction in smokers and people with COPD via forced oscillation technique and its association with biomarkers: a pilot study

American Journal of Physiology-Lung Cellular and Molecular Physiology 2026 Open access

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Authors: Prem Bhattarai, Maksim Grigorenko, Wenying Lu, Collin Chia, Steve Myers, Sukhwinder Singh Sohal, Andrew D. Williams
DOI: 10.1152/ajplung.00155.2025
Cited by: 3
References: 50

Abstract

This study highlights the utility of the forced oscillation technique (FOT) and biomarkers in detecting early airway changes in smokers and patients with COPD. FOT, along with biomarkers for airway remodeling can provide a sensitive measure and insight into early airway dysfunction, complementing traditional spirometry. These findings underscore the importance of early detection of airway abnormalities and the potential of FOT as a clinical tool for managing at-risk populations.

Fields of Study & Subjects

Chronic Obstructive Pulmonary Disease (COPD) Research Asthma and respiratory diseases Inhalation and Respiratory Drug Delivery

Publication details

Journal / source
American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher
American Physiological Society
Volume
330
Issue
3
Pages
L211–L221
Publication date
20 January 2026
Language
EN