Development of a novel potential difference probe with bedside validation simulator for potential difference testing

American Journal of Physiology-Lung Cellular and Molecular Physiology 2026

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Authors: David Odeke Otuya, Kadambari Vijaykumar, Justin Anderson, Nicholas M. Dechene, Sophia Zoghbi, Heather Y. Hathorne, E. Baker, Tara C. Lignelli, Anita S. Chung, Catriona N. Grant, B. Liu, George Marty Solomon
+2 more Guillermo J. Tearney, Steven M. Rowe
DOI: 10.1152/ajplung.00159.2025
Cited by: 0
References: 23

Abstract

Cystic fibrosis (CF) impairs CFTR protein function, disrupting ion transport and airway hydration. Traditional potential difference (PD) testing uses salt-bridge probes and calomel electrodes, but is error-prone due to air bubbles and poor visual guidance, especially in endobronchial applications. A novel probe with integrated silver-silver chloride electrodes, gas removal, and OCT guidance improves accuracy and usability. Validation through benchtop and preliminary human nasal testing shows 55% concordance with conventional methods, supporting its clinical potential.

Fields of Study & Subjects

Cystic Fibrosis Research Advances Analytical Chemistry and Sensors Ion Transport and Channel Regulation

Publication details

Journal / source
American Journal of Physiology-Lung Cellular and Molecular Physiology
Volume
330
Issue
2
Pages
L198–L210
Publication date
9 January 2026
Language
EN