Single-cell transcriptomics reveal alveolar macrophage-specific responses in single-hit ozone exposure model in mice
Abstract
This study addresses a critical knowledge gap regarding the response of alveolar macrophages to ozone, a potent inhaled toxicant. Specifically, we demonstrate that a single exposure to two experimentally relevant concentrations of ozone significantly alters functionally relevant gene expression in alveolar macrophages, as revealed by single-cell resolution analysis.
Fields of Study & Subjects
Air Quality and Health Impacts
Indoor Air Quality and Microbial Exposure
IL-33
ST2
and ILC Pathways
Publication details
- Journal / source
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 4
- Pages
- L318–L343
- Publication date
- 2 January 2026
- Language
- EN