cAMP-enriched extracellular vesicles improve outcomes in pulmonary hypertension

American Journal of Physiology-Lung Cellular and Molecular Physiology 2026 Open access

Read full text
Authors: Aritra Bhadra, Frederic Bonnie, Jenny L. Hewes, Mita Patel, J. Dennis Lee, Chun Zhou, Natalie Bauer
DOI: 10.1152/ajplung.00239.2025
Cited by: 2
References: 42

Abstract

Treatment with extracellular vesicles containing cyclic adenosine monophosphate (cAMP-EVs) improved outcomes of pulmonary hypertension in rats with hypoxia-induced pulmonary hypertension. Furthermore, the signaling events relative to these outcomes are likely endothelial-dependent and do not require the β-adrenergic receptor. These results suggest that cAMP-EVs help improve pulmonary hypertension and further our understanding of cAMP signaling in the pulmonary circulation.

Fields of Study & Subjects

Pulmonary Hypertension Research and Treatments Phosphodiesterase function and regulation Neonatal Respiratory Health Research

Publication details

Journal / source
American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
L169–L177
Publication date
26 January 2026
Language
EN