Contact-compression induces inflammatory and remodeling responses in bronchial epithelial cells

American Journal of Physiology-Lung Cellular and Molecular Physiology 2026

View at publisher
Authors: Akash M. Gupta, Janette Kay Burgess, Theo Borghuis, DJ Slebos, Simon D. Pouwels
DOI: 10.1152/ajplung.00247.2025
Cited by: 1
References: 47

Abstract

Our research introduces a novel in vitro model to study how contact-compressive stress drives pathological wound-healing responses in bronchial epithelial cells. By linking mechanical loading to mechanosensory-redistribution, cytoskeletal remodeling, and both pro-inflammatory ( CXCL8, IL6, IL1A, and GM-CSF) and profibrotic gene expression ( CTGF, COL1A1, and EGR1), this work provides critical insights into the cellular mechanisms underlying lung implant-associated complications and offers a platform for future biomaterial and device testing.

Fields of Study & Subjects

Connective Tissue Growth Factor Research Tissue Engineering and Regenerative Medicine Cardiac Fibrosis and Remodeling

Publication details

Journal / source
American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher
American Physiological Society
Volume
330
Issue
4
Pages
L304–L317
Publication date
30 January 2026
Language
EN