The impact of estrogen replacement during perimenopause on lung function and airway inflammation in the VCD mouse model

American Journal of Physiology-Lung Cellular and Molecular Physiology 2026 Open access

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Authors: William P. Pederson, Laurie M. Ellerman, Riley D. Hellinger, Joselyn Joanna Rojas Quintero, Francesca Polverino, John P. Konhilas, Julie G. Ledford
DOI: 10.1152/ajplung.00295.2025
Cited by: 0
References: 51

Abstract

Menopause-associated asthma is a subtype of asthma that is still largely unexplored and difficult to manage. Women experiencing menopause-associated asthma often have more severe exacerbations, higher rates of exacerbation, and most importantly, poor response to standard treatments. This study examined the impact of estrogen replacement given during the perimenopause phase on lung inflammation and function after menopause. While decreasing eosinophil recruitment, estrogen replacement actually led to worse lung function and more airway remodeling.

Fields of Study & Subjects

Asthma and respiratory diseases Menopause: Health Impacts and Treatments Estrogen and related hormone effects

Publication details

Journal / source
American Journal of Physiology-Lung Cellular and Molecular Physiology
Volume
330
Issue
4
Pages
L379–L389
Publication date
23 February 2026
Language
EN