Tumor necrosis factor α-induced endoplasmic reticulum stress promotes airway smooth muscle cell proliferation
Abstract
Airway hyperreactivity and hASM cell proliferation (hyperplasia) are hallmark characteristics of asthma. The results of the present study showed that short-term exposure of nonasthmatic hASM to TNFα (a proinflammatory cytokine) can also induce hASM cell proliferation via activation of an ER stress pathway. Identification of the ER stress signaling pathway as important in mediating hASM hyperplasia may provide an important therapeutic target for treating asthma or acute inflammation.
Fields of Study & Subjects
Endoplasmic Reticulum Stress and Disease
Autophagy in Disease and Therapy
Cystic Fibrosis Research Advances
Publication details
- Journal / source
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 3
- Pages
- L239–L252
- Publication date
- 7 January 2026
- Language
- EN