Intravascular hemolysis aggravates ventilator-induced lung injury in mice

American Journal of Physiology-Lung Cellular and Molecular Physiology 2026

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Authors: Maximilian Buttenberg, Victoria Bünger, Mahdi Taher, Nadja T. Hofer, Helen Rinderknecht, Borna Relja, Robert Klopfleisch, Roland C E Francis, Wolfgang M Kuebler, Jan A Graw
DOI: 10.1152/ajplung.00355.2025
Cited by: 1
References: 54

Abstract

Mechanical ventilation is frequently used in critically ill patients and can itself cause pulmonary damage. Furthermore, hemolysis is common in sepsis and ARDS. Mice receiving mechanical ventilation and an infusion of cell-free hemoglobin (CFH) demonstrated increased impairment of lung mechanics associated with lung edema not fully explainable by the proinflammatory and proedematous effects of CFH. Furthermore, increased plasma concentrations of CFH correlated with reduced pulmonary compliance in patients with severe ARDS and therapy with ECMO.

Fields of Study & Subjects

Respiratory Support and Mechanisms Immune Response and Inflammation Inflammation biomarkers and pathways

Publication details

Journal / source
American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher
American Physiological Society
Volume
330
Issue
6
Pages
L696–L707
Publication date
30 April 2026
Language
EN