3-Mercaptopyruvate sulfurtransferase regulates mitochondrial metabolism and epithelial differentiation in neonatal patient-derived airway cells

American Journal of Physiology-Lung Cellular and Molecular Physiology 2026 Open access

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Authors: Abhrajit Ganguly, Cynthia M. Carter, Aristides Rivera Negron, Paul T. Pierce, Lynette Kay Rogers, Matthew S. Walters, Y. S. Prakash, Trent E. Tipple, Arlan G Richardson
DOI: 10.1152/ajplung.00418.2025
Cited by: 1
References: 44

Abstract

This study identifies 3-mercaptopyruvate sulfurtransferase (MPST) as a previously unrecognized regulator of neonatal airway epithelial development. In our neonatal patient-derived three-dimensional organotypic model, hyperoxia reduces MPST, and MPST loss alters mitochondrial metabolism and epithelial differentiation programs. These findings indicate that MPST deficiency contributes to mitochondrial dysfunction under hyperoxic conditions and highlight MPST-linked pathways as potential therapeutic targets to mitigate early-life airway injury and remodeling relevant to infants with bronchopulmonary dysplasia (BPD).

Fields of Study & Subjects

Neonatal Respiratory Health Research Cancer Hypoxia and Metabolism Sulfur Compounds in Biology

Publication details

Journal / source
American Journal of Physiology-Lung Cellular and Molecular Physiology
Publisher
American Physiological Society
Volume
330
Issue
5
Pages
L557–L566
Publication date
28 March 2026
Language
EN