Low-dose simulated galactic cosmic radiation exposure after hindlimb unloading has long-term impact on skeletal muscle metabolic proteins in female mice

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2026

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Authors: Matthew Martone, Brian A. Irving, Guillaume Spielmann, Neil Michael Johannsen, Matthew M. Robinson, Jeffery C. Chancellor, Heather C M Allaway
DOI: 10.1152/ajpregu.00014.2026
Cited by: 1
References: 44

Abstract

Acute simGCRsim exposure causes changes in metabolic and mitochondrial protein abundance that are observable after 9 mo. Weight-bearing and unloaded muscle show unique metabolic protein profiles, with unloaded muscle experiencing reduced expression of glycolytic proteins relative to weight-bearing muscle after 9 mo. Significant dose-dependent response to acute simGCRsim exposure, with higher doses having more profound effects on metabolic and antioxidant protein abundance.

Fields of Study & Subjects

Spaceflight effects on biology Muscle Physiology and Disorders Exercise and Physiological Responses

Publication details

Journal / source
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Volume
330
Issue
6
Pages
R582–R589
Publication date
30 April 2026
Language
EN