Predictive modeling of putamen dopamine in Parkinson’s disease: relevance to prognosis, treatment, and prevention
Abstract
We used kinetic modeling to predict the temporal course of putamen dopamine depletion across the lifespan in Parkinson's disease and predict effects of autotoxicity, genetics, environmental exposures, and possible treatments on the timing of the onset of symptomatic disease.
Fields of Study & Subjects
Parkinson's Disease Mechanisms and Treatments
Neurological disorders and treatments
Neurotransmitter Receptor Influence on Behavior
Publication details
- Journal / source
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Volume
- 330
- Issue
- 5
- Pages
- R512–R529
- Publication date
- 28 March 2026
- Language
- EN