Postocclusive muscle reoxygenation kinetics and nitric oxide bioavailability following 10-day bed rest

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2026 Open access

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Authors: Giorgio Manferdelli, Letizia Rasica, Andrea Pilotto, Lucrezia Zuccarelli, Giovanni Baldassarre, Mia C. Burleigh, Chris Easton, Mauro Marzorati, Boštjan Šimunič, Rado Pišot, Marco Vincenzo Narici, Bruno Grassi
+1 more Simone Porcelli
DOI: 10.1152/ajpregu.00093.2025
Cited by: 0
References: 60

Abstract

Short-term (10 days) horizontal bed rest does not affect skeletal muscle microvascular function when assessed via near-infrared spectroscopy and postocclusion reactive hyperemia. However, both skeletal muscle resting oxygen consumption and nitric oxide bioavailability decrease following 10-days bed rest. Future studies should investigate the time course of changes in skeletal muscle microvascular function following longer period of microgravity/inactivity.

Fields of Study & Subjects

Spaceflight effects on biology Cardiovascular and exercise physiology Nitric Oxide and Endothelin Effects

Publication details

Journal / source
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Volume
330
Issue
4
Pages
R347–R355
Publication date
18 February 2026
Language
EN