Water intake mediates cross-sectional associations between urinary kidney injury biomarkers and race in emerging adults

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2026 Open access

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Authors: Jake P. Muma, Braxton A. Linder, Nina Lawrene Stute, Sofia O. Sanchez, Christin Domeier, Joseph C. Watso, Matthew C. Babcock, Roger S. Zoh, Orlando M. Gutiérrez, Zachary J. Schlader, Thomas E. Fuller‐Rowell, Austin T. Robinson
DOI: 10.1152/ajpregu.00097.2026
Cited by: 1
References: 87

Abstract

Apparently healthy emerging Black adults exhibited higher concentrations of several kidney injury biomarkers, collected via a 24-h urine sample, compared with White adults. Racial group differences in all kidney injury biomarkers tested, except for TIMP-2 × IGFBP7 (the only FDA-approved urinary kidney injury biomarker), were attenuated once indexed to urinary hydration markers. Water intake mediated the racial group difference in TIMP-2 × IGFBP7. Future work is needed to determine whether hydration interventions could mitigate racial differences in TIMP-2 × IGFBP7.

Fields of Study & Subjects

Thermoregulation and physiological responses Acute Kidney Injury Research Chronic Kidney Disease and Diabetes

Publication details

Journal / source
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Volume
331
Issue
2
Pages
R113–R126
Publication date
10 June 2026
Language
EN