The impact of muscle inactivity and exercise training on histidine-dipeptide homeostasis in rat skeletal muscle

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2026

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Authors: Amanda Romualdo Santana, Bianca Scigliano Vargas, Luiz Roberto Grassmann Bechara, Andressa C. Formalioni, Gabriella Berwig Möller, Maria Rita de Camargo Rodrigues, Wagner Ribeiro Pereira, B B da Silva, Karoline dos Prazeres Silva, Diego Pulzatto Cury, Hamilton Roschel, Anselmo Sigari Moriscot
+4 more Julio Cesar Batista Ferreira, M. S. De Medeiros, Lívia de Souza Gonçalves, Guilherme Giannini Artioli
DOI: 10.1152/ajpregu.00105.2025
Cited by: 0
References: 44

Abstract

This study demonstrated that an extreme model of muscle inactivity in rats (i.e., 12 wk of hindlimb paralysis following denervation) resulted in a substantial decline in muscle carnosine and anserine, which occurred irrespective of fiber type shift. Conversely, exercise training had no effect on histidine-dipeptide content. These findings, along with previously published studies, reinforce the notion that muscle inactivity is an important modulator of histidine-dipeptide homeostasis in skeletal muscle.

Fields of Study & Subjects

Biochemical effects in animals Muscle Physiology and Disorders Muscle metabolism and nutrition

Publication details

Journal / source
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Volume
330
Issue
4
Pages
R368–R378
Publication date
24 February 2026
Language
EN