Impact of inspiratory muscle training on inspiratory muscle metaboreflex in patients with heart failure with preserved ejection fraction

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2026 Open access

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Authors: Sophie Miller, Shane M. Hammer, Eric J. Bruhn, Barry A. Borlaug, Thomas P. Olson, Joshua R. Smith
DOI: 10.1152/ajpregu.00114.2026
Cited by: 1
References: 47

Abstract

Heart failure with preserved ejection fraction (HFpEF) is associated with exercise intolerance, with respiratory muscle dysfunction as a contributing factor. Patients with HFpEF have exaggerated cardiovascular responses to respiratory muscle metaboreflex activation. In this study, we determined the impact of inspiratory muscle training (IMT) on the respiratory muscle metaboreflex in HFpEF. We found that 8 wk of IMT improved inspiratory muscle strength and attenuated the respiratory muscle metaboreflex-mediated cardiovascular responses in patients with HFpEF.

Fields of Study & Subjects

Cardiovascular and exercise physiology Heart Rate Variability and Autonomic Control Chronic Obstructive Pulmonary Disease (COPD) Research

Publication details

Journal / source
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Volume
331
Issue
2
Pages
R283–R290
Publication date
17 July 2026
Language
EN