Limited effects of dietary nitrate supplementation with resistance training on skeletal muscle and vascular outcomes in middle-aged and older adults

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 2026

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Authors: Mason C. McIntosh, Breanna J. Mueller, Dakota Tiede, Derick A. Anglin, George J. Kontos, Daniel L. Plotkin, Madison L. Mattingly, Nicholas J. Kontos, J. Max Michel, Anthony Agyin-Birikorang, Kenneth Harrison, Brandon Peoples
+11 more Jaimie A. Roper, Dustyn T. Lewis, M. Kase Chirico, Harshini Kannan, Michael D. Goodlett, L. Bruce Gladden, Andrew D. Frugé, Austin T. Robinson, Andreas N. Kavazis, Darren T. Beck, Michael D. Roberts
DOI: 10.1152/ajpregu.00195.2025
Cited by: 2
References: 83

Abstract

Results from this study suggest that 12 wk of dietary nitrate supplementation does not significantly alter skeletal muscle hypertrophic, strength, or vascular outcomes in previously untrained middle-aged and older adults who performed resistance training.

Fields of Study & Subjects

Nitric Oxide and Endothelin Effects Cardiovascular and exercise physiology Exercise and Physiological Responses

Publication details

Journal / source
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
Publisher
American Physiological Society
Volume
330
Issue
2
Pages
R136–R150
Publication date
12 January 2026
Language
EN